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FIGURE and progesterone exert their biological effects via both genomic and nongenomic mechanisms. Nongenomic effects of estrogen have been reported to occur through the classical nuclear receptor that is localized to the membrane directly through palmitoylation of the receptor (B), through interactions with other proteins, such as caveolin (A) or MNAR and c-Src (C). Biologics or biologic drugs are products made from living organisms or contain components of living organisms. Biologics treat many conditions, for example, cancers, rheumatoid arthritis, inflammatory bowel disease, MS, psoriasis, lupus, chronic migraine, and hepatitis B. Side effects of a biologics depend upon the specific biologic drug.